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Tulsi, Holy Basil ct eugenol

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(Ocimum sanctum)
Mentally stimulating and supports healthy breathing and digestive function, soothes nervous tension and minor aches and pains.

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Tulsi, Holy Basil ct eugenol
Ocimum sanctum L. / Ocimum tenuiflorum L.

Plant Origin: India
Method: Steam distilled from plant
Cultivation: Unsprayed (grown organically but not certified)
Chemical Famliy: Phenol
Aroma: Fresh, Herbaceous, slightly spicy, warm, resembles a combination of Basil and Clove
Note (Evaporation Rate): Middle
Approximate Shelf Life: 3-4 years once opened		 Key Constituents from GC/MS Analysis: Lot# 110
beta caryophyllene 29.89%
eugenol 43.60%
beta elemene 12.07%
1,8 cineole 0.16%
methyleugenol 0.02%
 
Safety Information
Children: Not suitable due to potential skin irritation risk.

Pregnancy/Breastfeeding: Suitable, although there is a precautionary and controversial caution for oral use by breastfeeding mothers due to the possibility that the anticoagulant properties may pass into breast milk. Maximum dermal use level is 1%.

Medication/Health Condition: Caution Orally: May interact with Pethidine, MAOIs or SSRIs. Anticoagulant medication (such as aspirin, heparin, warfarin), Hemophilia Peptic Ulcer, Internal bleeding, and other Bleeding disorders, Major Surgery and Childbirth (up to one week before or after), Severe Hepatic (liver) or Renal (kidney) impairment, Hypertensive or Diabetic Retinopathy, Thrombocytopenia (decreased platelet count), Vasculitis.
[Contraindicated orally because Tulsi Holy Basil "may inhibit platelet aggregation based on in vitro data either for the oil or a major constituent." Essential Oil Safety ​by Tisserand/Young, page 117.]
Therapeutic Uses
Tulsi Basil essential oil may support, aid, ease, soothe, reduce, calm, relax, promote and/or maintain healthy function of the following:
Acne
Allergic reaction
Anti-inflammatory (joints, nerve pain)
Anti-oxidant
Anxiety
Bacteria
Blood Sugar Level
Calming
Candida
Complexion
Cortisol (see info from Dr. Lam below)
Cystitis
Diabetes
Digestion
Environmental toxins (diffuse)
Fatigue
Fungal
Headache
Immune
Insect deterrent
Joints
Mental (calm, stimulating, focus, strength, energy, clarity)  
Migraine
Mold (diffuse)
Muscle soreness
Nerve Pain
Nervous system
Pain
Parasites
Respiratory
Scabies
Soreness
Spasms
Stimulating - is an adptogen, meaning it can be stimulating and sedating depending on the body's need.
Sedating - is an adptogen, meaning it can be stimulating and sedating depending on the body's need.
Uplifting
Virus

Tulsi Basil is noted to be uplifting, mentally stimulating, balancing to emotions. Tulsi may help relieve joint and nerve pain, especially when combined with an anti-inflammatory such as Helichrysum, Roman or German Chamomile.

Research
Tulsi "has demonstrated anticarcinogenic effects against stomach cancer in mice, and against cell lines for human mouth cancer and mouse leukemia (Tisserand/Young)."  "Although holy basil oil contains two carcinogens, it demonstrates significant anticarcinogenic and antioxidant activity, and therefore no maximum use levels are required, in our opinion, in regard to carcinogenesis (Tisserand/Young)."

A report in 2010 shows oils high in Eugenol (Clove and Tulsi) were effective against Sabies (itch mite), killing mites within an hour of contact. Use at a 1% - 3% dilution to avoid skin irritation. Robert Tisserand commented in his Essential Oils for Healthy Skin class that: "Holy Basil is similar to Clove and is antifungal and antimicrobial with 1/2 less risk of Clove's eugenol."

Holy Basil Cortisol Benefits for Adrenal Fatigue
Dr. Lam: "The holy basil plant lowers cortisol, which enables multiple systems and organs to operate optimally. Along with a holistic lifestyle and advice from an adrenal fatigue specialist, holy basil cortisol benefits may provide support for the immune system, thyroid, brain, liver, and other key players in a properly functioning physiological ecosystem." 

"Ocimum sanctum L. or Ocimum tenuiflorum L, commonly known as the Holy Basil in English or Tulsi in the various Indian languages, is a important medicinal plant in the various traditional and folk systems of medicine in Southeast Asia. Scientific studies have shown it to possess antiinflammatory, analgesic, antipyretic, antidiabetic, hepatoprotective, hypolipidemic, antistress, and immunomodulatory activities. Preclinical studies have also shown that Tulsi and some of its phytochemicals eugenol, rosmarinic acid, apigenin, myretenal, luteolin, β-sitosterol, and carnosic acid prevented chemical-induced skin, liver, oral, and lung cancers and to mediate these effects by increasing the antioxidant activity, altering the gene expressions, inducing apoptosis, and inhibiting angiogenesis and metastasis. . . . This review summarizes the results related to the chemopreventive and radioprotective properties of Tulsi and also emphasizes aspects that warrant future research to establish its activity and utility in cancer prevention and treatment."

Acaricidal activity of eugenol based compounds against scabies, Passay, C. Mounsey, K. Stevenson, G. Davis, R. Arlian, L. Morgan, W. Vyszenski-Moher, D. andres, K. McCarthy, J.  PLoS One, Quintessential data base 2010. 3. Tragoolpua, Y. Jatisatienr, A. Phytotherapy Research, Anti-herpes simplex virus activities of Eugenia carophyllus (Spreng.) Bullock & S.G. Harrison and essential oil, eugenol, Quintessential data base, 2007.  

Antibacterial and antifungal properties of essential oil components, Knobloch, K. Pauli, A. Iberl, B. Weigand. H. Weis, N.  Journal of  Essential Oil Research, Quintessential data base, 1989. 

Potential of plant oils as inhibitors of Candida albicans growth, Devkatte, A.N. Zore, G.B. Karuppayil, S.M., FEMS Yeast Research, Quintessential data base, 2005.

"... eugenol may serve as local anesthetics for other pathological pain conditions in addition to its wide use in dental clinic."
 
"Considering the importance of this compound, the present review discusses its anti-inflammatory and antioxidant properties, demonstrating its mechanisms of action and therapeutic potential for the treatment of inflammatory diseases."

"Tulasi leaf powder was fed at the 1% level in normal and diabetic rats for a period of one month to explore the effect on fasting blood sugar, uronic acid, total amino acids, and the lipid profile in serum and tissue lipids. The results indicated a significant reduction in fasting blood sugar, uronic acid, total amino acids, total cholesterol, triglyceride, phospholipids and total lipids. In liver, total cholesterol, triglyceride and total lipids were significantly lowered. Total lipids were significantly reduced in kidney. In heart, a significant fall in total cholesterol and phospholipids was observed. All these observations indicate the hypoglycemic and hypolipidemic effect of Tulasi in diabetic rats."

"The findings from this study suggest that basil leaves may be prescribed as adjunct to dietary therapy and drug treatment in mild to moderate NIDDM."

Carcinogenic/ anticarcinogenic potential: Holy basil oil increased glutathione S-transferase activity in the stomach, liver and esophagus of mice by more than 78%, and significantly inhibited B[ a] P-induced squamous cell stomach carcinoma (Aruna & Sivaramakrishnan 1996). Holy basil oil showed significant chemopreventive activity against human mouth epidermal carcinoma (KB) and mouse leukemia (P388) cell lines, with respective IC50 values of 95 and 85 μg/ mL. The oil was more effective than three of the four positive control drugs (Manosroi et al 2005). Eugenol powerfully induces glutathione S-transferase in mice and displays antitumoral activity. Estragole and methyleugenol are rodent carcinogens when oral exposure is sufficiently high.

Application Suggestions (See Essential Oil Usage for more information and a Dilution Chart.)
Topical: Dilute with a carrier oil, unscented lotion or unscented cream and apply on area of concern or as desired. Test first to be sure it is adequately diluted and doesn't irritate the skin. Maximum dermal use level 1%. Consider using a roll-on applicator for ease of application of prediluted oil.

Children: Not suitable due to potential skin irritation risk.

Inhalation: Diffuse with other oils. Holy Basil should not be more than 10% in a diffused blend. Aromatically, Tulsi resembles a cross between Basil and Clove.

Internal: Holy Basil is suitable for internal use within safe parameters if such use is deemed appropriate. We feel that internal use is rarely *needed* and should only be used with respect for how concentrated the oils are. HEO does not advocate internal use of essential oils without appropriate knowledge and understanding of how to administer, for what purpose, how much, which essential oils, safety concerns and so on. In our experience, essential oils are generally more effective used topically with proper dilution or inhaled. Kurt Schnaubelt, Ph.D. notes that "French aromatherapy literature contains many references to using oils orally." He goes on to note that "generally 1 drop is always enough when ingesting essential oils." A potential toxicity hazard could occur when untrained people use essential oils orally and ingest too much.Keep in mind that while medical doctors or health care practitioners may prescribe essential oils for internal use, they are trained and experienced in the safe application of essential oils. It is not a matter of using "French" or "British" methods, it's a matter of experience and appropriate application. Click here for more information about internal usage.

Testimonies
The following anecdotal testimonies have not been reviewed by the FDA.
The products mentioned are not intended to diagnose, prevent, treat or cure disease.
Information shared on the HEO website is not intended to be a substitute for medical advice given by your trusted health care provider.
We believe that essential oils are provided by the Lord to support our health and well-being.
The Lord is our wisdom, protector and healer.
(Genesis 1:29-30, Ezekiel 47:12) 
1. My favorite blend to diffuse is a special blend I make with 7 mL Tulsi-Holy Basil, 6 mL Lemon and 2 mL Geranium. This cleans the air and seems to help us avoid illness. - Tia

2. When I have respiratory issues, I put a drop of Holy Basil into my palm, rub palms together and then inhale deeply for a few minutes. Clears my mind and lungs! I've also put a few drops in a pan of steaming water, remove from flame, put a towel over my head and inhale with my eyes closed. Sometimes I add Eucalyptus and/or Pine essential oils. Nice :-)  - Connie
Safety
Caution with oral use: May interact with pethidine, MAOIs or SSRIs, anticoagulant medication, major surgery, peptic ulcer, hemophilia or other bleeding disorders.

Eugenol content may inhibit blood clotting, cause skin sensitization (moderate risk), be a mucous membrane irritation (low risk).

Eugenol is part of the phenol chemical family, which are potentially irritating components to skin and mucus membranes. We suggest following dilution guidelines (above) and using for a short time rather than long-term to avoid risk. Avoid in a bath and using on sensitive skin such as those with dematitis, babies and young children.

Avoid contact with the eyes and other sensitive areas. Essential oils are both lipophilic and hydrophobic. Lipophilic means they are attracted to fat— like the membranes of your eyes and skin. They are also hydrophobic, meaning they do not like water. Applying a carrier oil will create another fat for the essential oil to be attracted to other than the membranes of the eyes or skin. Tisserand suggests: "With essential oils, fatty oil has been suggested as an appropriate first aid treatment, though the advantage of saline [eyewash] is that the eyes can be continually flushed, and this is less easy with fatty oil.” We are not aware of a case where essential oil in the eyes caused permanent injury or long-term discomfort, but if you feel concerned, please call your health care provider. 

References
Schnaubelt K. Advanced Aromatherapy, The Science of Essential Oil Therapy, Healing Arts Press, USA, 1998.
Tisserand, Robert; Young, Rodney, Essential Oil Safety: A Guide for Health Care Professionals, Elsevier Health Sciences UK (2013-12-02), page 204-205.
Tisserand, Robert: Essential Oils for Healthy Skin class.
Worwood, Valerie Ann, The Complete Book of Essential Oils and Aromatherapy, New World Library, 2016, page 269. 
 
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From Isaiah 58:11 & Jeremiah 29:11
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